Take the A2 Hanover-Dortmund freeway to the "Bielefeld-Zentrum" junction. Then take the A33 in the direction of Brilon as far as the "Wünnenberg-Haaren" junction, from there in the direction of Büren.
Coming from the south:
Take the A44 Kassel-Dortmund to the "Wünneberg-Haaren" interchange. From there in the direction of Büren or via the A44 Kassel-Dortmund to the "Büren" exit.
Coming from the west:
Take the A44 Dortmund-Kassel to the Geseke/Steinhausen exit. Keep right there in the direction of Büren. Or take the A44 Dortmund-Kassel highway to the "Büren" exit.
Coming from the east:
Via the B64 towards Paderborn, then via the B1 towards Salzkotten, from there towards Büren.